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Time Room Session
08:30-10:00 Auditorium
Auditorium
08:30
Towards clinical xenotransplantation: Clinical trials are underway today!

Dela Golshayan, Switzerland
Moderator
Dela Golshayan, Switzerland
Moderator
Megan Sykes, United States
Moderator
Megan Sykes, United States
Moderator
Tatsuo Kawai, United States
Discrepancies between nonhuman primates and humans – What we need to know before proceeding to clinical trials?
Tatsuo Kawai, United States
Discrepancies between nonhuman primates and humans – What we need to know before proceeding to clinical trials?
Kazuhiko Yamada, United States
Kidney: Thymic tissue transplantation to induce graft tolerance across xenogeneic barrier
Kazuhiko Yamada, United States
Kidney: Thymic tissue transplantation to induce graft tolerance across xenogeneic barrier
Muhammad M. Mohiuddin, United States
Cardiac Xenotransplantation: Knowledge gaps learned through human experience
Muhammad M. Mohiuddin, United States
Cardiac Xenotransplantation: Knowledge gaps learned through human experience
Kefeng Dou, People's Republic of China
Liver: Auxiliary liver xenograft for acute liver failure
Kefeng Dou, People's Republic of China
Liver: Auxiliary liver xenograft for acute liver failure
10:00-10:30 Atrium (Les Lianes)
Atrium (Les Lianes)
10:00
Coffee Break
10:30-12:00 Auditorium
Auditorium
10:30
IXA Special Lecture and Business Meeting

Muhammad M. Mohiuddin, United States
Moderator
Muhammad M. Mohiuddin, United States
Moderator
Wayne J Hawthorne, Australia
Introduction of Keith Reemtsma Award recipient
Wayne J Hawthorne, Australia
Introduction of Keith Reemtsma Award recipient
Peter Cowan, Australia
Keith Reemtsma Lecture Award
Peter Cowan, Australia
Keith Reemtsma Lecture Award
Muhammad M. Mohiuddin, United States
Introduction of the IXA Honorary Award recipient
Muhammad M. Mohiuddin, United States
Introduction of the IXA Honorary Award recipient
Leo Buhler, Switzerland
IXA Honorary Lecture Award
Leo Buhler, Switzerland
IXA Honorary Lecture Award
Rita Bottino, United States
Introduction of the Agnes Azimzadeh Award recipient
Rita Bottino, United States
Introduction of the Agnes Azimzadeh Award recipient
Curie Ahn, Korea
Agnes Azimzadeh Lecture Award
Curie Ahn, Korea
Agnes Azimzadeh Lecture Award
Muhammad M. Mohiuddin, United States
Business Meeting
Muhammad M. Mohiuddin, United States
Business Meeting
Muhammad M. Mohiuddin, United States
XenoPrize and David Cooper Awards
Muhammad M. Mohiuddin, United States
XenoPrize and David Cooper Awards
Muhammad M. Mohiuddin, United States
IXA, TTS, CareDx Awards and Swiss Grant Awards
Muhammad M. Mohiuddin, United States
IXA, TTS, CareDx Awards and Swiss Grant Awards
12:00 - 13:30 |  Lunch Break - 12:00 to 13:30
12:00-12:45 Atrium (Les Lianes)
Atrium (Les Lianes)
12:00
Coffee Break
12:45-13:20 Auditorium
Auditorium
12:45
Corporate Symposium: Gene Editing and Production of Organs from 10GE pigs for Clinical Xenotransplants and The Road to Xenotransplant Clinical Trials
Session Organized by:



David Ayares, United States
Gene editing and production of 10GE pigs for preclinical and clinical studies
David Ayares, United States
Gene editing and production of 10GE pigs for preclinical and clinical studies
Jayme Locke, United States
The road to xenotransplant clinical trials
Jayme Locke, United States
The road to xenotransplant clinical trials
13:30 - 15:00 |  Plenary Session - 13:30 to 15:00
13:30-15:00 Auditorium
Auditorium
13:30
Islets-cells the future is today…

Raphael Meier, United States
Moderator
Raphael Meier, United States
Moderator
Gregory S. Korbutt, Canada
Moderator
Gregory S. Korbutt, Canada
Moderator
Yannick Muller, Switzerland
CAR-T reg cell therapy
Yannick Muller, Switzerland
CAR-T reg cell therapy
Barbara Ludwig, Germany
Macroencapsulation of pig islets
Barbara Ludwig, Germany
Macroencapsulation of pig islets
Rita Bottino, United States
Composite islet-kidney xenotransplantation to cure both diabetes and kidney failure
Rita Bottino, United States
Composite islet-kidney xenotransplantation to cure both diabetes and kidney failure
Chung-Gyu Park, Korea
Pig islet transplantation – the optimal immunosuppressive protocol
Chung-Gyu Park, Korea
Pig islet transplantation – the optimal immunosuppressive protocol
15:05 - 15:55 |  Oral Abstract Sessions - 15:05 to 15:55
15:05-15:55 Auditorium
Auditorium
15:05
Pre- and Subclinical Models 1

Carmen Gonelle-Gispert, Switzerland
Moderator
Carmen Gonelle-Gispert, Switzerland Rapid-Fire
Moderator
Gisella L. Puga Yung, Switzerland
Moderator
Gisella L. Puga Yung, Switzerland Rapid-Fire
Moderator
Alex Sagar, United Kingdom
Extra-corporeal liver cross-circulation using transgenic porcine xenografts in the human decedent model
Alex Sagar, United Kingdom
Extra-corporeal liver cross-circulation using transgenic porcine xenografts in the human decedent model
Erwan Morgand, France
Multimodal phenotyping of pig-to-human heart xenografts' immune response
Erwan Morgand, France
Multimodal phenotyping of pig-to-human heart xenografts' immune response
Ahmad Karadagi, United States
Multiple human transgenes prolong survival of triple-carbohydrate knockout porcine kidney xenografts in nonhuman primates
Ahmad Karadagi, United States
Multiple human transgenes prolong survival of triple-carbohydrate knockout porcine kidney xenografts in nonhuman primates
Tao Li, People's Republic of China
Brain-dead human subjects as preclinical models for xenotransfusion: Feasibility and safety of genetically engineered pig red blood cell transfusion
Tao Li, People's Republic of China
Brain-dead human subjects as preclinical models for xenotransfusion: Feasibility and safety of genetically engineered pig red blood cell transfusion
Sho Takemoto, United States
Combined 11-gene-editing with HLA-E expression and donor macrophage depletion extends survival in pig-to-baboon lung xenotransplantation
Sho Takemoto, United States
Combined 11-gene-editing with HLA-E expression and donor macrophage depletion extends survival in pig-to-baboon lung xenotransplantation
15:05-15:55 H8-01-D
H8-01-D
15:05
Organ Xenotransplant - Clinical Application 3

Shaoping Deng, People's Republic of China
Moderator
Shaoping Deng, People's Republic of China Rapid-Fire
Moderator
Muhammad M. Mohiuddin, United States
Moderator
Muhammad M. Mohiuddin, United States Rapid-Fire
Moderator
Robert Woodward, United States
Blood cell gene expression in xenotransplantation of genetically modified pig heart into human recipient: Comparison to human allotransplantation
Robert Woodward, United States
Blood cell gene expression in xenotransplantation of genetically modified pig heart into human recipient: Comparison to human allotransplantation
Javier Galindo, United States
Correlation of left ventricular global longitudinal strain with NT-proBNP in the first and second genetically modified porcine to human xeno heart transplant
Javier Galindo, United States
Correlation of left ventricular global longitudinal strain with NT-proBNP in the first and second genetically modified porcine to human xeno heart transplant
Sarah T Cipriano, United States
Establishing correlation of non-invasive monitoring techniques in xenotransplantation
Sarah T Cipriano, United States
Establishing correlation of non-invasive monitoring techniques in xenotransplantation
Alice Tang, United States
Invasive versus echocardiographic hemodynamics in two genetically modified porcine to human cardiac xenotransplants
Alice Tang, United States
Invasive versus echocardiographic hemodynamics in two genetically modified porcine to human cardiac xenotransplants
Alexandra K Hawkins, United States
Nursing experience caring for a porcine kidney xenotransplant recipient
Alexandra K Hawkins, United States
Nursing experience caring for a porcine kidney xenotransplant recipient
15:05-15:55 H8-01-F
H8-01-F
15:05
Innate Immunity and Inflammation 1

Jörg D Seebach, Switzerland
Moderator
Jörg D Seebach, Switzerland Rapid-Fire
Moderator
Philippe Morel, Switzerland
Moderator
Philippe Morel, Switzerland Rapid-Fire
Moderator
Megan R Dufault, United States
Neutrophil Extracellular Trap (NET) formation after xenotransplantation: A potential contributor to inflammation and thrombodysregulation
Megan R Dufault, United States
Neutrophil Extracellular Trap (NET) formation after xenotransplantation: A potential contributor to inflammation and thrombodysregulation
Valentin Goutaudier, France
Spatial multimodal characterization of long-term immune response after pig-to-human kidney xenotransplantation
Valentin Goutaudier, France
Spatial multimodal characterization of long-term immune response after pig-to-human kidney xenotransplantation
Ekaterina Umnyakova, Switzerland
Exploring the efficacy of complement-modulating protective coatings for porcine endothelial cells via combination of metabolic glycoengineering and click chemistry
Ekaterina Umnyakova, Switzerland
Exploring the efficacy of complement-modulating protective coatings for porcine endothelial cells via combination of metabolic glycoengineering and click chemistry
Soichi Matsumura, Japan
Expression of plexin-B2 on swine endothelial cells suppresses neutrophil-mediated cytotoxicity in xenotransplantation models
Soichi Matsumura, Japan
Expression of plexin-B2 on swine endothelial cells suppresses neutrophil-mediated cytotoxicity in xenotransplantation models
Martin V Kolev, United Kingdom
Complement inhibition in xenotransplantation - why, what and when?
Martin V Kolev, United Kingdom
Complement inhibition in xenotransplantation - why, what and when?
15:55 - 16:20 |  Coffee Break - 15:55 to 16:20
15:55-16:20 Atrium (Les Lianes)
Atrium (Les Lianes)
15:55
Coffee Break
16:20 - 17:05 |  Mini-Oral Abstract Sessions - 16:20 to 17:05
16:20-17:05 Auditorium
Auditorium
16:20
Pre- and Subclinical Models 2

Paolo Brenner, Germany
Moderator
Paolo Brenner, Germany
Moderator
Wayne J Hawthorne, Australia
Moderator
Wayne J Hawthorne, Australia
Moderator
Kohei Kinoshita, United States
Retention of a native kidney with ureter ligation compensates for renin-angiotensin system function after pig-to-baboon kidney transplantation
Kohei Kinoshita, United States
Retention of a native kidney with ureter ligation compensates for renin-angiotensin system function after pig-to-baboon kidney transplantation
William B Swicord, United States
Cardiac xenograft as a bridge to allotransplantation in a non-human primate model: Lessons learned
William B Swicord, United States
Cardiac xenograft as a bridge to allotransplantation in a non-human primate model: Lessons learned
Muhammed Esad Gunes, United States
GLP preclinical trial of pig-to-baboon thymokidney xenotransplantation using inbred GalT-KO miniature swine donors
Muhammed Esad Gunes, United States
GLP preclinical trial of pig-to-baboon thymokidney xenotransplantation using inbred GalT-KO miniature swine donors
Daniel L Eisenson, United States
Incomplete cross-species regulation of complement associated with 10 GE Xenokidney failure in life-supporting pig-to-baboon transplantation
Daniel L Eisenson, United States
Incomplete cross-species regulation of complement associated with 10 GE Xenokidney failure in life-supporting pig-to-baboon transplantation
Javier Galindo, United States
A survival analysis of pig-to-non-human primate orthotopic heart transplants
Javier Galindo, United States
A survival analysis of pig-to-non-human primate orthotopic heart transplants
Javier Galindo, United States
Pre-transplant anti-porcine antibodies do not predict xenograft survival in pig-to-non-human primate orthotopic heart transplantation
Javier Galindo, United States
Pre-transplant anti-porcine antibodies do not predict xenograft survival in pig-to-non-human primate orthotopic heart transplantation
16:20-17:05 H8-01-D
H8-01-D
16:20
Small Animals and In Vitro

Alban Longchamp, United States
Moderator
Alban Longchamp, United States
Moderator
Mitra Gultom, Switzerland
Moderator
Mitra Gultom, Switzerland
Moderator
Adrian Mutto, Argentina
Sequential genome editing enhances triple-knockout efficiency and human transgene expression in porcine fibroblasts for xenotransplantation
Adrian Mutto, Argentina
Sequential genome editing enhances triple-knockout efficiency and human transgene expression in porcine fibroblasts for xenotransplantation
Megan R Dufault, United States
Transgenic HLA-E on porcine endothelial cells attenuates human NK cytotoxicity and degranulation via CD94/NKG2A-mediated inhibition
Megan R Dufault, United States
Transgenic HLA-E on porcine endothelial cells attenuates human NK cytotoxicity and degranulation via CD94/NKG2A-mediated inhibition
Sho Takemoto, United States
Modulating human neutrophil rolling on porcine endothelium: Effects of Sialoadhesin and GPIb blockade combined with genetic engineering under microvascular flow
Sho Takemoto, United States
Modulating human neutrophil rolling on porcine endothelium: Effects of Sialoadhesin and GPIb blockade combined with genetic engineering under microvascular flow
Thao Tran, Switzerland
Expression of human CD47 in a novel transgenic pig protects porcine endothelial cells partially from NK cell cytotoxicity
Thao Tran, Switzerland
Expression of human CD47 in a novel transgenic pig protects porcine endothelial cells partially from NK cell cytotoxicity
Mitra Gultom, Switzerland
Complement regulation in genetically modified pig endothelial cells under xenogeneic and inflammatory conditions
Mitra Gultom, Switzerland
Complement regulation in genetically modified pig endothelial cells under xenogeneic and inflammatory conditions
Daviana Munoz Cruz, Switzerland
Quantification of islet cell cluster size heterogeneity in the juvenile porcine pancreas
Daviana Munoz Cruz, Switzerland
Quantification of islet cell cluster size heterogeneity in the juvenile porcine pancreas
Nizar I Mourad, Belgium
Macroencapsulated transgenic InsGLP-1M3R neonatal porcine islets reverse diabetes in immunocompetent rats
Nizar I Mourad, Belgium
Macroencapsulated transgenic InsGLP-1M3R neonatal porcine islets reverse diabetes in immunocompetent rats
16:20-17:05 H8-01-F
H8-01-F
16:20
Innate Immunity and Inflammation 2

Gisella L. Puga Yung, Switzerland
Moderator
Gisella L. Puga Yung, Switzerland
Moderator
Mohamed B. Ezzelarab, United States
Moderator
Mohamed B. Ezzelarab, United States
Moderator
Zhongqiang Zhang, People's Republic of China
The impact of innate immune cell activation in genetically engineered pig-to-nonhuman primate orthotopic liver xenotransplantation
Zhongqiang Zhang, People's Republic of China
The impact of innate immune cell activation in genetically engineered pig-to-nonhuman primate orthotopic liver xenotransplantation
Valentin Goutaudier, France
Application of a novel spatial transcriptomic 6000-plex panel in pig-to-human xenotransplantation
Valentin Goutaudier, France
Application of a novel spatial transcriptomic 6000-plex panel in pig-to-human xenotransplantation
Wanseop Kim, Korea
Histopathologic evaluation of cardiac xenotransplantation - A review of 13 autopsy cases
Wanseop Kim, Korea
Histopathologic evaluation of cardiac xenotransplantation - A review of 13 autopsy cases
Aprajita Mattoo, United States
The histologic identification of IgA deposits in three cases of porcine to human Xenokidney transplantation
Aprajita Mattoo, United States
The histologic identification of IgA deposits in three cases of porcine to human Xenokidney transplantation
Jean Kwun, United States
A novel IgG and IgM cleaving endopeptidase, iceMG, for xenotransplantation
Jean Kwun, United States
A novel IgG and IgM cleaving endopeptidase, iceMG, for xenotransplantation
Imad Aljabban, United States
Human xenoreactive antibodies against porcine aortic endothelial cells
Imad Aljabban, United States
Human xenoreactive antibodies against porcine aortic endothelial cells
17:10 - 18:45 |  Plenary Session - 17:10 to 18:45
17:10-18:45 Auditorium
Auditorium
17:10
Mentoring the future: A session to inspire young investigators

Raphael Meier, United States
Moderator
Raphael Meier, United States
Moderator
Konrad Fischer, Germany
Moderator
Konrad Fischer, Germany
Moderator
Asghar Ali, Germany
Breeding vs cloning
Asghar Ali, Germany
Breeding vs cloning
Hiromitsu Nakauchi, United States
Xenotransplantation: the blastocyst complementation route
Hiromitsu Nakauchi, United States
Xenotransplantation: the blastocyst complementation route
Alexandre Loupy, France
BANFF classification for Kidney, Heart and Liver xenograft pathology
Alexandre Loupy, France
BANFF classification for Kidney, Heart and Liver xenograft pathology
Megan Sykes, United States
Xenotransplantation - five decades of progress
Megan Sykes, United States
Xenotransplantation - five decades of progress
Jeffrey Stern, United States
Initial clinical experience with compassionate-use kidney xenotransplantation -the young investigator perspective
Jeffrey Stern, United States
Initial clinical experience with compassionate-use kidney xenotransplantation -the young investigator perspective
Discussion Period, Switzerland
Panel discussion and audience Q&A
Discussion Period, Switzerland
Panel discussion and audience Q&A
18:45-19:45 Auditorium
Auditorium
18:45
Young Investigator Networking Reception
19:00 - 23:00 |  Networking Events
20:00-23:00 Bateau Genève - Quai Gustave-Ador 1
Bateau Genève - Quai Gustave-Ador 1
20:00
Congress Dinner
Email: info@ixa2025.org
514-874-1717