Check out the online IXA 2025 Program

Time	Room	Session
09:15-10:30	Auditorium	Auditorium 09:15 Opening Ceremony Full Details Leo Buhler, Switzerland Welcome address by Congress Chair Leo Buhler, Switzerland Welcome address by Congress Chair Pierre Maudet, Switzerland State Councillor; Head of the Department of Health and Mobility, Republic and Canton of Geneva Pierre Maudet, Switzerland State Councillor; Head of the Department of Health and Mobility, Republic and Canton of Geneva Deusdedit Mubangizi, Switzerland World Health organization (WHO) Deusdedit Mubangizi, Switzerland World Health organization (WHO) Franz Immer, Switzerland Welcome from Swisstransplant Society Franz Immer, Switzerland Welcome from Swisstransplant Society Antoine Geissbuhler, Switzerland Université de Genève, Dean of the Faculty of Medicine Antoine Geissbuhler, Switzerland Université de Genève, Dean of the Faculty of Medicine Muhammad M. Mohiuddin, United States Welcome from the IXA President Muhammad M. Mohiuddin, United States Welcome from the IXA President Leo Buhler, Switzerland Closing remarks Leo Buhler, Switzerland Closing remarks
10:30-11:00	Atrium (Les Lianes)	Atrium (Les Lianes) 10:30 Coffee Break Full Details
11:00-12:30	Auditorium	Auditorium 11:00 Advanced technologies in clinical xenotransplantation: Genetics and multi-omics Full Details Alexandre Loupy, France Moderator Alexandre Loupy, France Moderator Jay A. Fishman, United States Moderator Jay A. Fishman, United States Moderator Elisabeth Kemter, Germany Current perspectives for genetic modification in xenotransplantation Elisabeth Kemter, Germany Current perspectives for genetic modification in xenotransplantation Sagar Chhangawala, United States A Comprehensive NGS Strategy for Characterization of Genome Engineered Porcine Donors for Clinical Xenotransplantation Sagar Chhangawala, United States A Comprehensive NGS Strategy for Characterization of Genome Engineered Porcine Donors for Clinical Xenotransplantation Alexandre Loupy, France Multimodal phenotyping of clinical xenografts: Insights into the host immune response Alexandre Loupy, France Multimodal phenotyping of clinical xenografts: Insights into the host immune response Brendan Keating, United States Integrative multi-omic profiling in clinical xenotransplantation Brendan Keating, United States Integrative multi-omic profiling in clinical xenotransplantation
12:30 - 13:30 \| Lunch Break - 12:30 to 13:30
12:30-13:30	Atrium (Les Lianes)	Atrium (Les Lianes) 12:30 Lunch Break Full Details
13:00-13:30	H8-01-D	H8-01-D 13:00 Meet & Greet with the Young Investigator Committee Please collect your lunch in the Atrium first Full Details Raphael Meier, United States Facilitator Raphael Meier, United States Facilitator
13:30 - 15:00 \| Plenary Session - 13:30 to 15:00
13:30-15:00	Auditorium	Auditorium 13:30 Ethics-economics-regulation: Does the public buy in? Full Details Franz Immer, Switzerland Moderator Franz Immer, Switzerland Moderator Emanuele Cozzi, Italy Moderator Emanuele Cozzi, Italy Moderator Richard N Pierson III, United States Overview of IXA ethics committee structure and function Richard N Pierson III, United States Overview of IXA ethics committee structure and function Daniel Hurst, United States Religious perspectives regarding the ethical issues associated with clinical xenotransplantation Daniel Hurst, United States Religious perspectives regarding the ethical issues associated with clinical xenotransplantation Ralf R. Tönjes, Germany Xenotransplantation in view of the European Council Ralf R. Tönjes, Germany Xenotransplantation in view of the European Council Efstratios (Stratos) Chatzixiros, Switzerland Xeno regulation, safety: Current status and emerging initiatives Efstratios (Stratos) Chatzixiros, Switzerland Xeno regulation, safety: Current status and emerging initiatives Discussion Period, Switzerland Panel discussion and audience Q&A Discussion Period, Switzerland Panel discussion and audience Q&A
15:05 - 15:55 \| Oral Abstract Sessions - 15:05 to 15:55
15:05-15:55	Auditorium	Auditorium 15:05 Organ Xenotransplant - Clinical Application 1 Full Details Richard N Pierson III, United States Moderator Richard N Pierson III, United States Rapid-Fire Moderator Pierre R Gianello, Belgium Moderator Pierre R Gianello, Belgium Rapid-Fire Moderator Edward Skolnik, United States Incidence and management of proteinuria in a living recipient of a 10 gene-edit xenokidney transplant Edward Skolnik, United States Incidence and management of proteinuria in a living recipient of a 10 gene-edit xenokidney transplant Jayme Locke, United States Study design of the first-in-human clinical trial of a 10 gene-edited xenokidney Jayme Locke, United States Study design of the first-in-human clinical trial of a 10 gene-edited xenokidney Raphael Meier, United States Endothelial injury and fibrogenesis drives post-transplant response after pig-to-human heart xenotransplantation Raphael Meier, United States Endothelial injury and fibrogenesis drives post-transplant response after pig-to-human heart xenotransplantation Michael A. Cole, United States Complement monitoring in cardiac xenotransplantation: Insights from the second porcine-to-human live heart transplant Michael A. Cole, United States Complement monitoring in cardiac xenotransplantation: Insights from the second porcine-to-human live heart transplant Sarah L Leventhal, United States Clinical correlations with longitudinal echocardiography and left ventricular global longitudinal strain in the first and second genetically modified porcine to human cardiac xenotransplantations Sarah L Leventhal, United States Clinical correlations with longitudinal echocardiography and left ventricular global longitudinal strain in the first and second genetically modified porcine to human cardiac xenotransplantations
15:05-15:55	H8-01-D	H8-01-D 15:05 Genetic Engineering 1 Full Details Elisabeth Kemter, Germany Moderator Elisabeth Kemter, Germany Rapid-Fire Moderator Dengke Pan, People's Republic of China Moderator Dengke Pan, People's Republic of China Rapid-Fire Moderator Yong Wang, People's Republic of China The expression of human erythropoietin in pig kidneys can mitigate the problem of anemia after kidney transplantation Yong Wang, People's Republic of China The expression of human erythropoietin in pig kidneys can mitigate the problem of anemia after kidney transplantation Asghar Ali, Germany Genetically modified Auckland Island pigs as organ source for xenotransplantation Asghar Ali, Germany Genetically modified Auckland Island pigs as organ source for xenotransplantation Zheng Hu, People's Republic of China Exploring primate immune responses to SLA-deficient pig xenografts in humanized mice and rhesus monkeys Zheng Hu, People's Republic of China Exploring primate immune responses to SLA-deficient pig xenografts in humanized mice and rhesus monkeys Yusuke Yanagino, Japan Study of the suppression on innate immune induced rejection by homo HO-1 and sus scrofa HO-1 Yusuke Yanagino, Japan Study of the suppression on innate immune induced rejection by homo HO-1 and sus scrofa HO-1 Andrea Perota, Italy Targeted insertions of human transgenes combining CRISPR/Cas9 and Cre/lox-RMCE for generation of genetic engineered-pigs for xenotransplantation Andrea Perota, Italy Targeted insertions of human transgenes combining CRISPR/Cas9 and Cre/lox-RMCE for generation of genetic engineered-pigs for xenotransplantation
15:05-15:55	H8-01-F	H8-01-F 15:05 Ethics and Regulation Full Details Emanuele Cozzi, Italy Moderator Emanuele Cozzi, Italy Rapid-Fire Moderator Nicolas Johannes Mueller, Switzerland Moderator Nicolas Johannes Mueller, Switzerland Rapid-Fire Moderator Macey L. Levan, United States The longest-living human with a xenograft: A qualitative narrative inquiry Macey L. Levan, United States The longest-living human with a xenograft: A qualitative narrative inquiry Macey L. Levan, United States Toward a patient-centered definition of success in kidney xenotransplantation: A qualitative study of two long-term recipients Macey L. Levan, United States Toward a patient-centered definition of success in kidney xenotransplantation: A qualitative study of two long-term recipients Anthony Merlocco, United States Ethical pursuit of expanded xenotransplantation and potential for disability bias in pediatric patients Anthony Merlocco, United States Ethical pursuit of expanded xenotransplantation and potential for disability bias in pediatric patients Luz Padilla, United States Public attitudes toward xenotransplantation: A national survey Luz Padilla, United States Public attitudes toward xenotransplantation: A national survey Heather Murphy, United States Patient perspectives of kidney xenotransplantation: A survey by the National Kidney Foundation (NKF) Heather Murphy, United States Patient perspectives of kidney xenotransplantation: A survey by the National Kidney Foundation (NKF)
15:55 - 16:20 \| Coffee Break - 15:55 to 16:20
15:55-16:25	Atrium (Les Lianes)	Atrium (Les Lianes) 15:55 Coffee Break Full Details
16:20 - 17:10 \| Mini-Oral Abstract Sessions - 16:20 to 17:10
16:20-17:10	Auditorium	Auditorium 16:20 Organ Xenotransplant - Clinical Application 2 Full Details Carmen Gonelle-Gispert, Switzerland Moderator Carmen Gonelle-Gispert, Switzerland Moderator Burcin Ekser, United States Moderator Burcin Ekser, United States Moderator Angeles Baquerizo, United States Differential pig and human protein abundance in plasma of patients exposed to pig hepatocytes following bioartificial liver treatments Angeles Baquerizo, United States Differential pig and human protein abundance in plasma of patients exposed to pig hepatocytes following bioartificial liver treatments Alexander C Schulick, United States Screening human blood products for xeno-reactive antibodies to ensure compatibility in clinical xenotransplantation Alexander C Schulick, United States Screening human blood products for xeno-reactive antibodies to ensure compatibility in clinical xenotransplantation Robert Woodward, United States Monitoring donor-derived cell free DNA in porcine heart xenotransplant recipients Robert Woodward, United States Monitoring donor-derived cell free DNA in porcine heart xenotransplant recipients Jeffrey Stern, United States Real-time intraoperative quantification of xenograft blood flow into a porcine xenothymokidney in a living human with a left ventricular assist device Jeffrey Stern, United States Real-time intraoperative quantification of xenograft blood flow into a porcine xenothymokidney in a living human with a left ventricular assist device Javier Galindo, United States Correlation of left ventricular global longitudinal strain with porcine cell-free DNA in the first & second genetically modified porcine to human xeno heart transplant Javier Galindo, United States Correlation of left ventricular global longitudinal strain with porcine cell-free DNA in the first & second genetically modified porcine to human xeno heart transplant Tal Eitan, United States Pig kidney xenograft size after pig-to-human transplantation - GGTA1 KO Thymokidney vs 10 GE Xenokidney Tal Eitan, United States Pig kidney xenograft size after pig-to-human transplantation - GGTA1 KO Thymokidney vs 10 GE Xenokidney Takayuki Hirose, Japan How many potential candidates are there for clinical kidney xenotransplantation in Japan? Takayuki Hirose, Japan How many potential candidates are there for clinical kidney xenotransplantation in Japan?
16:20-17:10	H8-01-D	H8-01-D 16:20 Genetic Engineering 2 Full Details Peter Cowan, Australia Moderator Peter Cowan, Australia Moderator Elisabeth Kemter, Germany Moderator Elisabeth Kemter, Germany Moderator Chung Young Kim, Korea Biocompatibility of genetically-engineered pig cornea in corneal xenotransplantation for the use of human clinical trials Chung Young Kim, Korea Biocompatibility of genetically-engineered pig cornea in corneal xenotransplantation for the use of human clinical trials Yiyi Xuan, Hong Kong Genome-engineered porcine expanded potential stem cells as a novel cellular source for xenotransplantation Yiyi Xuan, Hong Kong Genome-engineered porcine expanded potential stem cells as a novel cellular source for xenotransplantation Nayoung Ko, Korea Identification of the potential role of swine leukocyte antigen in xenotransplantation Nayoung Ko, Korea Identification of the potential role of swine leukocyte antigen in xenotransplantation Kyungmin Kwak, Korea Human thrombomodulin-expressing Transgenic pigs for islet xenotransplantation: Potential Implication for pancreatic function and disease Kyungmin Kwak, Korea Human thrombomodulin-expressing Transgenic pigs for islet xenotransplantation: Potential Implication for pancreatic function and disease Yong Wang, People's Republic of China Overexpression of human CD55 in tripple knocout (TKO) porcine red blood cells (pRBC) can further reduce human antibody-induced hemolytic reactions Yong Wang, People's Republic of China Overexpression of human CD55 in tripple knocout (TKO) porcine red blood cells (pRBC) can further reduce human antibody-induced hemolytic reactions Konrad Fischer, Germany A novel transgene to regulate oxidative stress and mitochondrial damage Konrad Fischer, Germany A novel transgene to regulate oxidative stress and mitochondrial damage
16:20-17:10	H8-01-F	H8-01-F 16:20 Methodology / Technical Resources Full Details Alexandre Loupy, France Moderator Alexandre Loupy, France Moderator Ik Jin Yun, Korea Moderator Ik Jin Yun, Korea Moderator Joon Young Jang, Korea Early xeno-derived cell-free DNA elevation as a noninvasive biomarker of kidney xenograft rejection in pig-to-nonhuman primate xenotransplantation Joon Young Jang, Korea Early xeno-derived cell-free DNA elevation as a noninvasive biomarker of kidney xenograft rejection in pig-to-nonhuman primate xenotransplantation Kenta Iwasaki, Japan Immunopeptidomic identification of SLA-derived HLA class II ligands recognized by human T cells, using a strategy adapted for xenotransplantation Kenta Iwasaki, Japan Immunopeptidomic identification of SLA-derived HLA class II ligands recognized by human T cells, using a strategy adapted for xenotransplantation Xing Xiangyang, People's Republic of China Establishment of a designated pathogen-free (DPF) donor pig population of genetically edited pigs in Neijiang, China Xing Xiangyang, People's Republic of China Establishment of a designated pathogen-free (DPF) donor pig population of genetically edited pigs in Neijiang, China Gisella L. Puga Yung, Switzerland SLA antibody screening using Auckland island pig cells: Toward standardized diagnostics for xenotransplantation Gisella L. Puga Yung, Switzerland SLA antibody screening using Auckland island pig cells: Toward standardized diagnostics for xenotransplantation Luiz Gustavo Cano Munhoz, Brazil Standardization of multiplex qPCR assays for detection of PCMV and PCV2 in organ donor pigs Luiz Gustavo Cano Munhoz, Brazil Standardization of multiplex qPCR assays for detection of PCMV and PCV2 in organ donor pigs Philip Sommer, United States Successful somatic support of brain-dead decedents for xenotransplantation research: A systematic review and case series Philip Sommer, United States Successful somatic support of brain-dead decedents for xenotransplantation research: A systematic review and case series Barbara Ludwig, Germany Optimized cryopreservation of porcine pancreatic islet cells: A novel protocol for single-cell biobanking Barbara Ludwig, Germany Optimized cryopreservation of porcine pancreatic islet cells: A novel protocol for single-cell biobanking
17:15 - 18:45 \| Plenary Session - 17:15 to 18:45
17:15-18:45	Auditorium	Auditorium 17:15 Complement and humoral rejection: Still barriers to success? Full Details Manuel A. Pascual, Switzerland Moderator Manuel A. Pascual, Switzerland Moderator Peter Cowan, Australia Moderator Peter Cowan, Australia Moderator Robert Rieben, Switzerland Human anti-pig antibodies and the porcine endothelial glycolandscap Robert Rieben, Switzerland Human anti-pig antibodies and the porcine endothelial glycolandscap Robert A Montgomery, United States DSA and pre-screening Robert A Montgomery, United States DSA and pre-screening Alfred Joseph Tector, United States Anti-SLA antibodies in early renal xenograft loss Alfred Joseph Tector, United States Anti-SLA antibodies in early renal xenograft loss Daniel Ricklin, Switzerland The potential of pharmacological complement inhibitors for xenotransplantation Daniel Ricklin, Switzerland The potential of pharmacological complement inhibitors for xenotransplantation
18:40-20:30	Atrium	Atrium 18:40 Welcome Reception Supported by: Full Details Supported by:
18:45 - 20:30 \| Poster Session 1 and Welcome Reception - 18:45 to 20:30
18:45-20:30	Atrium	Atrium 18:45 Poster Session 1 - September 30 from 18:45 to 20:30 Full Details Hee Jung Kang, Korea Improving pig red blood cell transfusion safety with anti-CD154 co-administration in nonhuman primates Hee Jung Kang, Korea Improving pig red blood cell transfusion safety with anti-CD154 co-administration in nonhuman primates Anja MB Jensen, Denmark Xenotransplantation hope: Flying pigs and the people who make it happen Anja MB Jensen, Denmark Xenotransplantation hope: Flying pigs and the people who make it happen Hyeonji Jeon, Korea Brain-dead donors in xenotransplantation research: Global trends and legal-ethical challenges in Korea Hyeonji Jeon, Korea Brain-dead donors in xenotransplantation research: Global trends and legal-ethical challenges in Korea Jun-Hyeong Kim, Korea Production and characterization of transgenic pigs for xenotransfusion by knock-in of human CD46 and TBM or CD59 and CD47 genes at the GGTA1 exon4 locus Jun-Hyeong Kim, Korea Production and characterization of transgenic pigs for xenotransfusion by knock-in of human CD46 and TBM or CD59 and CD47 genes at the GGTA1 exon4 locus Sang Eun Kim, Korea Blood-derived endothelial progenitor cells enable non-terminal verification of endothelial-specific transgene expression in GTKO/MCP/TBM pigs Sang Eun Kim, Korea Blood-derived endothelial progenitor cells enable non-terminal verification of endothelial-specific transgene expression in GTKO/MCP/TBM pigs Kasinath V Kuravi, United States Generation of 10 gene pigs in one step with combination of CRISPR/CAS9 and 2A self-cleaving multigene expression system Kasinath V Kuravi, United States Generation of 10 gene pigs in one step with combination of CRISPR/CAS9 and 2A self-cleaving multigene expression system Mayuko Kurome, Germany Interspecies chimerism with human expanded potential stem cells in porcine embryos Mayuko Kurome, Germany Interspecies chimerism with human expanded potential stem cells in porcine embryos Keon B Oh, Korea Site-specific integration of HO1 and CD47 at the CMAH locus in GTKO pigs for immunomodulation in xenotransplantation Keon B Oh, Korea Site-specific integration of HO1 and CD47 at the CMAH locus in GTKO pigs for immunomodulation in xenotransplantation Joachim Denner, Germany Expression of a retroviral immunosuppressive protein on the xenotransplant – A way to reduce pharmacological immunosuppression? Joachim Denner, Germany Expression of a retroviral immunosuppressive protein on the xenotransplant – A way to reduce pharmacological immunosuppression? Heinke Heymer, Germany LEA29Y expression affects myocardial scar formation after ischemia/reperfusion in pigs Heinke Heymer, Germany LEA29Y expression affects myocardial scar formation after ischemia/reperfusion in pigs Siwon Hwang, Korea Bispecific anti-CD40LxCD28 antibody prevents mouse xenogeneic GVHD Siwon Hwang, Korea Bispecific anti-CD40LxCD28 antibody prevents mouse xenogeneic GVHD Karen Khalil, United States Dosing of pegcetacoplan with plasmapheresis for treatment of xenoantibody mediated rejection Karen Khalil, United States Dosing of pegcetacoplan with plasmapheresis for treatment of xenoantibody mediated rejection Ji Woo Shin, Korea Immunomodulatory ability of porcine peripheral blood-derived mesenchymal stem cells in xenotransplantation Ji Woo Shin, Korea Immunomodulatory ability of porcine peripheral blood-derived mesenchymal stem cells in xenotransplantation Yusuke Yanagino, Japan Suppressive effect of mycophenolic acid on the cytotoxicity of human macrophages against swine endothelial cells Yusuke Yanagino, Japan Suppressive effect of mycophenolic acid on the cytotoxicity of human macrophages against swine endothelial cells Daniel Hurst, United States Attitudes toward pig islet xenotransplantation for type 1 diabetes: A scoping review Daniel Hurst, United States Attitudes toward pig islet xenotransplantation for type 1 diabetes: A scoping review Beom Seok Kim, Korea Optimizing aCD154-free immunosuppression and monitoring in QKO pig-to-monkey islet xenotransplantation Beom Seok Kim, Korea Optimizing aCD154-free immunosuppression and monitoring in QKO pig-to-monkey islet xenotransplantation Ivan J. Ma, Canada Islet recovery and functionality retained after 24-hour static cold storage of neonatal porcine pancreas in University of Wisconsin solution Ivan J. Ma, Canada Islet recovery and functionality retained after 24-hour static cold storage of neonatal porcine pancreas in University of Wisconsin solution Juan OIFRPA Chen, People's Republic of China Nanodelivery of IL 33 locally amplifies the ILC2 and Treg to protect the graft in islet transplantation Juan OIFRPA Chen, People's Republic of China Nanodelivery of IL 33 locally amplifies the ILC2 and Treg to protect the graft in islet transplantation Yanick Fanton, Belgium Supply chain flexibility for a porcine beta cell replacement therapy to treat type 1 diabetes Yanick Fanton, Belgium Supply chain flexibility for a porcine beta cell replacement therapy to treat type 1 diabetes Jianmin Wu, People's Republic of China Targeting the activity of beta cells by membrane surface redox regulation for islet transplantation Jianmin Wu, People's Republic of China Targeting the activity of beta cells by membrane surface redox regulation for islet transplantation Elisabeth Kemter, Germany Unravelling the dynamic process of NPI maturation at the single cell transcriptome level Elisabeth Kemter, Germany Unravelling the dynamic process of NPI maturation at the single cell transcriptome level W Lee, Korea Genetic diversity and population structure of GTKO-engineered Xeno pigs across generations based on SNP analysis W Lee, Korea Genetic diversity and population structure of GTKO-engineered Xeno pigs across generations based on SNP analysis Ernesto Goulart, Brazil Preliminary results of obtaining designated pathogen-free pigs in a pig facility for xenotransplantation in Brazil Ernesto Goulart, Brazil Preliminary results of obtaining designated pathogen-free pigs in a pig facility for xenotransplantation in Brazil Ernesto Goulart, Brazil Comparison of morphological quality of fetal fibroblasts fsed in nuclear transfer for swine embryo production for xenotransplantation Ernesto Goulart, Brazil Comparison of morphological quality of fetal fibroblasts fsed in nuclear transfer for swine embryo production for xenotransplantation Robert C McCarthy, United States A rational design method for tissue dissociation enzyme optimization (RDMTDE method) Robert C McCarthy, United States A rational design method for tissue dissociation enzyme optimization (RDMTDE method) Andrew G Breite, United States An ancillary material supplier's perspective on ISO 20399:2022 Andrew G Breite, United States An ancillary material supplier's perspective on ISO 20399:2022 Ludmila Garcia, Brazil Quality systems driving innovation: Implementing QMS, QA, and QC for genetically modified pigs in xenotransplantation Ludmila Garcia, Brazil Quality systems driving innovation: Implementing QMS, QA, and QC for genetically modified pigs in xenotransplantation Ivana Juric, France Mapping the evolution of solid organ xenotransplantation research: a systematic review Ivana Juric, France Mapping the evolution of solid organ xenotransplantation research: a systematic review Sun Ae Hwang, Korea Fabrication strategy of parathyroid organoids and their applicability for non-clinical primate transplantation Sun Ae Hwang, Korea Fabrication strategy of parathyroid organoids and their applicability for non-clinical primate transplantation

12:30 - 13:30 | Lunch Break - 12:30 to 13:30

13:30 - 15:00 | Plenary Session - 13:30 to 15:00

15:05 - 15:55 | Oral Abstract Sessions - 15:05 to 15:55

15:55 - 16:20 | Coffee Break - 15:55 to 16:20

16:20 - 17:10 | Mini-Oral Abstract Sessions - 16:20 to 17:10

17:15 - 18:45 | Plenary Session - 17:15 to 18:45

18:45 - 20:30 | Poster Session 1 and Welcome Reception - 18:45 to 20:30