Introduction: To explore the changing trend of cardiac function after allogeneic heterotopic heart transplantation with transgenic edited pig hearts, and the influence of the receptor's immune response on the donor heart, providing an experimental basis for the application of gene editing technology in the clinical field.
Methods: From December 16, 2023 to March 17, 2025, four cases of allogeneic and ectopic heart transplants between pigs and rhamus monkeys were completed. The functional status of transplanted plants under the load state after transplantation and the immune indicators of the recipients were observed.
Results: The longest case of recipient monkey has survived for 46 days and no hyperacute or acute immune rejection reactions have occurred. Pathological analysis showed minor myocardial damage in the monkey heart but more severe damage in the porcine heart, suggesting chronic immune rejection.
Conclusion: Transgenic editing technology offers the possibility of xenotransplantation, but its clinical application still requires further in-depth research.